Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases
نویسندگان
چکیده
منابع مشابه
Osteoimmunology in rheumatic diseases
This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed significantly to the understanding of joint destruction in rheumatoid arthritis and other forms of arthropathies. In particular, the molecular regulation of osteoclast formation and its control by proinflamm...
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Inflammatory rheumatic disorders, such as rheumatoid arthritis (RA) and connective tissue diseases, are characterized by chronic inflammation that generally can be overcome by lifelong administration of immunosuppressive therapies. In most of these diseases, factors of genetic predisposition have been described, in particular the influence of distinct HLA haplotypes. In addition, environmental ...
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The field of osteoimmunology has emerged in response to the range of evidences demonstrating the close interrelationship between the immune system and bone metabolism. This is pertinent to immune-mediated diseases, such as rheumatoid arthritis and periodontal disease, where there are chronic inflammation and local bone erosion. Periprosthetic osteolysis is another example of chronic inflammatio...
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Background and purpose: Treatment of rheumatic diseases depends on proper use of medications. The aim of this study was to evaluate the frequency and reasons for discontinuation of drugs in these patients. Materials and methods: A cross-sectional study was performed in patients with inflammatory rheumatic diseases in Sari, Iran 2020-2021 to investigate the frequency and reasons for discontinua...
متن کاملInflammatory Rheumatic Disorders and Bone
Inflammatory joint diseases such as rheumatoid arthritis, as well as other rheumatic conditions, such as systemic lupus erythematosus (SLE) and ankylosing spondylitis, comprise a heterogeneous group of joint disorders that are all associated with extra-articular side effects, including bone loss and fractures. The concept of osteoimmunology is based on growing insights into the links between th...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.00679